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This is a two part paper about aspirations and obstacles for transdisciplinary research. The first part is a theoretical reflection on what it means to take transdisciplinarity serious and how it might help to change our worlds through research in a responsible and socially inclusive manner. With the first part, I suggest thinking about how we construct our publics, alliances and relations in our research practices. The second part of the paper adds reflections on a practical exercise of transdisciplinary intra-action among the Changing Worlds 2014 Conference participants. The hope of the overall paper is to inspire more tools, moments and interventions of transdisciplinary intra-action in the social sciences and beyond.